Commonly prescribed for: Estrus suppression in the female, for behavioral management of intact male dogs and cats, and to manage feline psychogenic dermatitis and alopecia
Species: Dogs, Cats, and Horses
Therapeutic Class: Long-acting Synthetic Progesterone
Medroxyprogesterone acetate (MPA) is long-acting synthetic progesterone. It is used commonly in women as an injectable contraceptive. Oral MPA is used in women to treat bleeding disturbances associated with the menstrual cycle. MPA blocks the secretion of pituitary hormones and has a marked effect on ACTH and cortisol release. MPA also has an anti-insulin effect and decreases testosterone in male humans and male dogs.
MPA historically has been used for estrus suppression in the female, for behavioral management of intact male dogs and cats, and to manage feline psychogenic dermatitis and alopecia. There are many side-effects associated with MPA use in dogs and cats and recent literature has focused on the use of alternative drugs. All use of MPA in dogs and cats is extra-label and it should be used only when other treatment options have been tried and found unsuccessful.
MPA is used for estrus suppression in performance horse mares and to diminish inappropriate sexual behavior in "studish" geldings. There also is some thought that progestins such as MPA may calm the behavior of "hot" horses. This is an extrapolation based on work done with progestins in other species.
Although the published studies on its use do not show any effect on estrus suppression, there are many practitioners who feel that they have seen a positive response. Anecdotally, there are some mares that respond well to MPA and others that do not seem to respond at all. The gold-standard drug for estrus suppression in the mare is altrenogest.
Remember to tell your veterinarian about any medications, vitamins, supplements, or herbal therapies that you are giving to your pet.
No information regarding overdose was found in the literature.
Wedgewood provides medication options that help ensure accurate dosing, especially for hard to medicate pets. Click below for a complete list of Wedgewood’s dosing forms and strengths.
DOSAGE FORM | BENEFITS | STRENGTHS |
---|---|---|
Injectable Solution | Sterile solution intended for injection. | 150 mg/ml-300mg/ml |
Tablet | Compressed dry ingredients in a solid oral dosage form. | 2.5 mg/tab-10 mg/tab |
View all Medroxyprogesterone Acetate options